indigestion with glp 1 GLP-1 nausea: How to handle GLP-1s' most common side effect Your guide to GLP-1 side

doi: 10.1126/scitranslmed.aar7047 [DOI] [PubMed] [Google Scholar] 101

In 1957, Jean Stern converted the blood glucose-lowering potential of metformin in therapy for T2DM: he observed that, in subjects with maturity-onset diabetes, metformin could replace or reduce the need for insulin without the occurrence of frank hypoglycemia [19,20,21,22,23]

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Current therapeutic approachesincluding supraphysiologic insulin( 19 ), insulin sensitizers( 20 ), leptin( 21, 22 ), and insulin-like growth factor-1 (IGF-1)( 2329 )provide limited metabolic benefit and do not correct the underlying receptor signaling defect