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For persistent symptoms, intra-articular corticosteroid injections or duloxetine may be appropriate adjunctive therapies

Differences in cancer outcome definitions across trials were addressed by grouping clinically equivalent endpoints (e.g., hepatocellular carcinoma and primary liver cancer) and accounting for heterogeneity through random-effects modeling, sensitivity analyses, and GRADE downgrading for indirectness where appropriate

Because tirzepatide targets both GLP-1 and GIP receptors, researchers are evaluating whether dual agonist therapies may produce even greater functional improvement in obesity-related osteoarthritis

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