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NONCLINICAL TOXICOLOGY Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females

Musculoskeletal syndrome of menopause, a recently proposed clinical term, describes the collective impact of arthralgia, bone loss, muscle loss, and osteoarthritis progression during this period [14]

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Trial data suggests modest regain on switching (about 1 kg from injectable Wegovy, about 5 kg from injectable Mounjaro over a year)