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While it launched initially as a diabetes drug, early studies revealed its effectiveness for weight loss, prompting many health care providers to prescribe it off-label for weight loss

Conclusion Overall, tirzepatide produced significant health and weight-related QoL improvements versus comparators in the five SURPASS studies

Int J Obes 32(7):S109S19 Hjorth MF, Roager HM, Larsen TM, Poulsen S, Licht TR, Bahl MI, Zohar Y, Astrup A (2018) Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention