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We emphasize that the curves in Figure 4 and the numerical values in Table 1 are not precise estimates as they result from very simple calculations (detailed in the Supplementary Appendix)

Left heart dysfunction Left ventricle Traditionally, the primary pathophysiologic mechanism of elevated filling pressures and exercise intolerance in patients with HFpEF has been attributed to diastolic dysfunction of the left ventricle (LV)

Packer shares his thoughts on the term guideline directed medical therapy, guidelines in general, and the challenges of using the ejection fraction to measure systolic function

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