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This is particularly surprising given that i.c.v administration is a standard route to test central effects of drugs in animal studies, and a large number of studies have injected GLP1 or GLP1 receptor agonists and antagonists into the ventricular system in order to explore direct effects of GLP1 receptor activation within the CNS (Meeran et al., 1999

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Some examples of GLP receptor agonists include exenatide (Byetta, Bydureon), liraglutide (Victoza, Saxenda), semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound, Mounjaro)

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