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VDR is associated with the intestinal barrier function, immune responses, and colitis, and it is also vital for the activation of NFB and the expression of tight junction proteins in the intestinal flora ( 3 [1,25(OH) 2 D 3 ], an active form of vitamin D, can directly interact with the intestinal flora and resist the lipopolysaccharides or TNF- ( 2 D 3 in the serum, but VDR expression can be down-regulated by pathogenic species such as Salmonella typhimurium in the intestine (Wu et al., 2010)

This extended duration is why you typically inject once weekly rather than daily

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You may need to restart the titration from a lower dose, depending on how long you have been off