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On the basis of these findings, the overall efficacy and safety of tirzepatide has been investigated in the SURPASS clinical trial programme in comparison with placebo and other glucose-lowering medications including GLP-1 RAs and basal insulin [11]

Eva Varoqua, MD, Lexington Family Practice White Knoll

The inhibition of GSIS by lowering glucose levels was similar though between somatostatin knockout and wild-type mice

2011;301:F35563
