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The headline finding: total lean mass declined by 10.9% over that period

The economic burden is considerable: annual direct healthcare costs attributable to MASLD in the United States and Europe are estimated in the tens of billions of dollars, driven by hospitalizations, liver-related procedures, and management of comorbid conditions [6]

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Moreover, ALA-PDT modulates serum high-mobility group box 1 (HMGB1) levels and macrophage morphology, thereby contributing to enhanced antitumor immunity (192)