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Patients were randomized to receive weekly subcutaneous semaglutide 2.4 mg or placebo, with a mean follow-up of 39.8 months

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Deng et al

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How to increase tirzepatide dose properly When you and your clinician decide to move up, a careful process helps minimize setbacks: Advance in 2.5 mg steps only after 4 weeks on the current dose (e.g., from 5 mg to 7.5 mg), unless your clinician recommends waiting longer

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The reduction of these factors is considered to be one of the key mechanisms by which GLP-1RAs exert a protective effect by inhibiting inflammatory responses [12]

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