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In March 2019, Eli Lilly stated that they receive $135 per month for each patient who takes the average prescribed amount of Humalog U-100 after rebates (which is 4.5x Canadas transparent net price)
However, only the injectable form has been available because peptide drugs are usually not suitable for administration via the oral route, as they present low oral bioavailability, are inactivated when they reach the gastrointestinal tract, and have low rates of diffusion into the cell [31, 32]
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