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For thyroid C-cell tumors specifically, the FDA requires a boxed warningthe agency's strongest safety warningfor several products including semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), exenatide extended-release (Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)

Since muscle is a major energy utilizer 17,41 , minimizing muscle mass during caloric restriction can substantially reduce energy expenditure, thus sparing energy for the maintenance of other more critical organ systems 42,43,44

doi: 10.1161/CIRCULATIONAHA.122.059595

Semaglutide does not appear on standard drug screening panels used for employment, legal, or clinical purposes