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For researchers who have a history of emetic sensitivity, this difference alone might influence which protocol they choose

Some patients and providers use very slow titration or lower maintenance doses to stay within a tolerable range (Jastreboff et al., NEJM 2022)

Once stable at a therapeutic dose, additional compounds can be reintroduced one at a time

A few important caveats before you read that as a definitive win for retatrutide: Trial design differences matter: Phase 2 vs
