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They found that MASH-related histologic changes and noninvasive test responses (including histologic resolution of MASH without worsening of liver fibrosis, ALT responses, and FibroScan AST [FAST] responses), as well as fibrosis-related histologic improvement and noninvasive test responses (including improvement in fibrosis without worsening of MASH, VCTE responses, and ELF score responses), were greater in patients receiving semaglutide than in patients receiving placebo, even at a similar amount of weight reduction

For those who may be apprehensive about injections, Mounjaro's delivery system includes a retractable needle, making the process more comfortable

Of the 21 patients who were randomized, those treated with orlistat showed significant improvements in the 6MWT, New York Heart Association (NYHA) functional classification, and weight loss when compared to the placebo group