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Extrapolating from semaglutide and tirzepatide data is reasonable given shared molecular characteristics (large protein-based structures, poor oral bioavailability), but it is not the same as having direct evidence

The analysis revealed that weight loss accounted for only 13% and 21% of the improvement in HOMA2-IR with tirzepatide (10 mg and 15 mg, respectively), indicating that weight loss was only partially responsible for the observed improvements in insulin resistance

The data does not suggest semaglutide is ineffective only that tirzepatide delivers more

While vaginal atrophy may not be reversed, women don't have to endure the discomfort