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Its proposed mechanisms include: 1

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In particular, the prefrontal cortex (PFC), amygdala, and hippocampus are crucial for regulating emotion, stress responses, and motivation

Accompanying symptoms include: Intense joint pain that may be described as excruciating Visible swelling and redness around the affected joint Warmth to touch over the inflamed area Extreme tenderness even light touch or bedsheets may be unbearable Restricted movement of the affected joint Occasionally, low-grade fever and general malaise Symptoms may resolve spontaneously over 7-14 days even without treatment, but medical assessment is important to confirm the diagnosis, provide symptomatic relief, and prevent future attacks