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Furthermore, validation has been achieved with small molecules such as GSK137647A, which activates the Free Fatty Acid Receptor 4 (FFAR4, also known as GPR120), and with Sinigrin, an agonist of the Bitter Taste Receptor 38 (TAS2R38)

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474 At week 8, patients with moderate to severe UC treated with 45 mg upadacitinib showed significant improvement, with 46% reporting no intestinal urgency and 38% reporting no symptoms of abdominal pain

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