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Description
Design Systematic review and network meta-analysis

This dual synthetic polypeptide, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 receptor agonist (GLP-1 RA) acts through incretin pathways and stimulates insulin sensitivity while slowing gastric emptying

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However, the insulinotropic effect of incretins is diminished in type 2 diabetic patients, due in part to reduced expression of incretin receptors as a consequence of glucotoxicity
