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Its typically most pronounced at the beginning of treatment and sometimes when dosage is increased

As semaglutide reduces weight and improves metabolic parameters, the original medication dose may become excessive, potentially causing hypotension (abnormally low blood pressure), dizziness, or fatigue

While the numbers we estimate are for Great Britain as a whole, it is noteworthy that the number using these medications for weight loss far exceeds the initial expectation for NHS England to provide treatment for 220,000 people in the first 3 years, which is likely to have important consequences for NHS budgets, although our estimate is less than the number eligible according to NICE guidelines (3.4 million) [14]

In Alzheimers Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial