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Issa, MD, PhD Dr

Bupropion is whats called a norepinephrine-dopamine reuptake inhibitormeaning it keeps dopamine and norepinephrine active in the brain for longer than they would be otherwise

It targets three key hormone receptors at the same time: GLP-1 (glucagon-like peptide-1) Stimulates insulin release Reduces glucagon secretion Helps regulate blood sugar GIP (glucose-dependent insulinotropic polypeptide) Enhances insulin response Improves insulin sensitivity Glucagon Receptors Increases energy expenditure Promotes satiety and appetite control This triagonist design offers a multifaceted attack on metabolic dysfunction, addressing blood sugar, appetite, and energy usage all at once

In weight management trials, only ~1% of participants were 75+, with no overall efficacy differences in those 65+ vs younger, but potential greater sensitivity