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IQVIA data confirms combined Zepbound and Wegovy new patient starts increased 34% year-over-year in 2025

5,6 In addition, receptor activator of nuclear factor kappa beta ligand (RANKL), that plays a crucial role in osteoclast activity and bone resorption, 21 also directly influences pancreatic beta-cell function and overall metabolism, with its activity being compromised in obesity and T2D

In action, semaglutide influences how different regions of your brain communicate signals like hunger, satiety, or cravings

She encourages practitioners to frame GLP-1 therapies as tools to jumpstart change, not as long-term solutions