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In fact, it often produces worse outcomes because severe nausea leads to dehydration, nutritional deficiency, and sometimes medication discontinuation

In rats, induction of gut glucagon-like immunoreactivity induced by either lipids or by physiological concentrations of GIP can be blocked by subdiaphragmatic vagotomy, suggesting that in rats GIP regulation of GLP-1 secretion requires either afferent or efferent signal transmission via the vagus [327]

Rubino D, Abrahamsson N, Davies M, et al

The company reported favorable Phase 3 results last month, saying that it is on track to submit the drug for regulatory approval by year-end