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semaglutide prediabetes weight loss trial progression to diabetes Two-year effects of in adults with overweight or obesity: the STEP 5 Long-term weight loss effects of
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The result: Increased glucose-dependent insulin secretion Reduced glucagon release Better control of fasting & postprandial glucose Weight-neutral therapy with minimal risk of hypoglycemia A simple yet effective mechanism that plays a powerful role in modern diabetes management

this finding should be interpreted cautiously given the retrospective design, active and non-inert comparator, and likelihood of residual confounding
