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For people on medications like semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and orforglipron (Foundayo), experts say its vital to have strategies in place to prevent dehydration, which can pose serious health risks

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A 2025 study published in Psychopharmacology "Semaglutide, Tirzepatide, and Retatrutide Attenuate the Interoceptive Effects of Alcohol in Male and Female Rats" specifically tested all three drugs in animal models