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Description
Beyond MMP inhibition, leptin-induced TIMP-1 promotes myocardial fibrosis via CD63/1-integrin signaling in cardiac fibroblasts [173]
This approach aligns with current American Association of Clinical Endocrinologists guidelines recommending GLP-1 monotherapy as first-line pharmacotherapy for weight management in most patient populations
Combining a stimulant (phentermine) with a GLP-1 agonist can elevate blood pressure and heart rate unpredictably
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