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See our guide on best time of day to take semaglutide Step 5: Rule out medical factors Get thyroid levels checked (TSH, free T3, free T4) Check for insulin resistance markers (fasting insulin, HOMA-IR) Review current medications for weight-promoting side effects Assess for conditions that impair weight loss response When to switch medications or sources Sometimes the best answer is not to fix your current compounded semaglutide but to change course entirely