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Type 2 diabetes is associated with obesity, compared to type 1 diabetes which is often associated with a genetic cause of diabetes seen in juveniles that are not necessarily overweight

The Obesity Society (2025) Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension

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80 While the clinical significance of this heart rate increase remains uncertain, it raises theoretical concerns in patients with ischemic heart disease or arrhythmias and may counteract some of the antihypertensive benefit of GLP-1 RAs