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pentobarbital (80 mg kg 1 ), followed by injection of collagenase (1.14 mg ml 1
These were originally investigated for diabetes, on the theory that GLP-1 increases insulin and thus decreases blood sugar
However, statistical mediation analyses from trials such as SELECT suggest that only a portion of the MACE reduction is explained by weight loss alone, pointing to direct, weight-independent vascular and cardiac benefits [12,66]
The results of these trials have consistently demonstrated the cardiovascular benefits associated with GLP-1 receptor agonists including reductions in major adverse cardiovascular events
