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Insulin and sulfonylureas should be considered only as a last resort, as increased insulin levels may reactivate the PI3K pathway, counteracting the antitumor effects of PI3K inhibition (256,259)
Consistent with these effects, direct activation of GLP-1Rs in the VTA is sufficient to attenuate cocaine seeking 8
Also, self-reporting cant always be consistently reliable
Keep multiple sizes on hand if your dose changes frequently
