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doi: 10.1136/gutjnl-2013-305112 97 FengJPetersenCDCoyDHJiangJKThomasCJPollakMRet al

Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)