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Aspirin reduces circulating free fatty acids and TG levels in obese patients with type-2 diabetes and increases fat breakdown during fasting in healthy humans, which can be explained by the direct effect of aspirin on AMPK activation [4]

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Cardiac Conditions That May Require Medical Clearance Patients with a history of heart attack, stroke, or unstable angina need physician evaluation before starting semaglutide, though the medication is not contraindicated in these groups
