dual gip/glp-1 receptor agonist Tirzepatide's Unique Mechanism of Action The mechanisms of dual incretin

Using themselves as subjects and RIA, they demonstrated that people experience higher insulin levels when they eat sugar than when it is injected into their bloodstream (McIntyre, Holdsworth, Turner)

Cardia L, de Cleva R, Ferreira L, Gadducci AV, Estabile P, Santos Silva PR, et al

These findings, revealed more than a decade after the first approval of twice-daily exenatide in 2005, have rekindled enthusiasm for the use of GLP-1R agonists, alone or in combination, in the treatment of T2D and obesity, most compellingly in subjects at high risk for cardiovascular disease

In mice, genetic deletion or pharmacologic inhibition of DPP4 is able to increase the homing of CXCR4+ EPC at sites of myocardial damage, resulting in a reduced cardiac remodeling and improved heart function and survival (200)