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GLP-1 additionally exerts various effects outside the pancreas, including regulation of food intake and appetite (12), inhibition of gastrointestinal motility and secretion (13) and a cardioprotective effect (14,15)

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Further, administration of exogenous ghrelin in food-sated individuals mimics the enhancement of brain BOLD response to food cues induced by fasting, whereas GLP-1R antagonism prevents the reduction of brain reactivity to food cues after consuming a meal