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Mitochondrial dysfunction is considered to play an underlying role in bipolar disorder, and abnormal accumulation of mitochondrial Ca 2+ is a potent trigger of necrosis, apoptosis, and autophagy [15,16,17,18]

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Model J.F.A., Lima M.V., Ohlweiler R., Sarapio E., Vogt .L., Rocha D.S., de Souza S.K., Vinagre A.S

HWR reports receiving research support for clinical trials, service as principal investigator, on advisory boards, speaking and consulting from Eli Lilly and Co, Esperion, Bayer, Boehringer Ingelheim, Novo Nordisk, Sanofi, and Zealand

doi: 10.1038/nrn3961 202 CandeiasESebastioICardosoSCarvalhoCSantosMSOliveiraCRet al