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Who Should Avoid This Combination: Safety and Contraindication Screening Patients with a history of cardiovascular disease, uncontrolled hypertension, arrhythmias, or coronary artery disease should not combine semaglutide with phentermine without extensive cardiologic evaluation

Excess adiposity is a particular overarching challenge in the treatment of type 2 diabetes because weight control can benefit so many of the other unmet needs by reducing metabolic stress to beta cells, improving insulin sensitivity and independently reducing the risk of associated morbidities [6]
Weight Loss Goals: Your desired weight loss goals and timeline can influence your choice

Dispose properly: Place used syringes in a sharps container