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Endocrinology (2017) 158(12):421832

That includes: People with severe kidney disease People who are pregnant or planning to become pregnant People aged 65 and older with a history of certain conditions, such as heart disease, liver disease, coma, or diabetic ketoacidosis People who consume high amounts of alcohol each week, which constitutes 8 or more drinks for individuals assigned female at birth (typically, women) and 15 or more drinks for individuals assigned male at birth (typically men) Lastly, some medications can interact with metformin and increase your risk for severe side effects

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Clinical trials with liraglutide showed not only a significant increase in satiety sensation, but also a notable reduction in the desire for sugar-, fat-, and salt-rich foods, accompanied by modifications in the hormonal profile, particularly in peptide YY (PYY) levels