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Fasting insulin values were available in 28 participants, with insulin resistance, defined as high homeostatic model assessment for insulin resistance (HOMA-IR) 1.9 [15], being reported in 24 out of 28 cases (86%), while severe insulin resistance, defined as HOMA-IR exceeding 4, being recorded in 15 out of 28 participants (53.5%)

So researchers looked at the medical records of more than 3,000 people with hormone receptor-positive DCIS on hormonal therapy and GLP-1s, as well as an equal number of people with hormone receptor-positive DCIS who were not taking GLP-1s

[3] [4] 5 kg of weight loss per week, though individual responses vary considerably depending on age, sex, hormonal status, and metabolic health

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