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Description
GLP-1 medications are contraindicated in patients with youal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

A 2024 meta-analysis (Sattar et al., Lancet Diabetes Endocrinol) found that switching from semaglutide to tirzepatide produced an additional 4.2 kg mean weight loss over 40 weeks, even when semaglutide had been titrated to maximum dose

Physiology of Weight Regain: Lessons From the Classic Minnesota Starvation Experiment on Human Body Composition Regulation

We will discuss proposed mechanisms in the following section
