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Reduced Nutrient Intake GLP-1 medications reduce appetite, making it easier to consume fewer caloriesbut sometimes fewer nutrients as well

Hazard of 5%, 10%, and 15% Weight Loss Among the matched population at risk (undergoing treatment), 81.8% (95% CI, 79.8%-83.7%) receiving tirzepatide vs 66.5% (95% CI, 64.3%-68.7%) receiving semaglutide achieved 5% or greater weight loss, 62.1% (95% CI, 59.7%-64.3%) vs 37.1% (95% CI, 34.6%-39.4%) achieved 10% or greater weight loss, and 42.3% (95% CI, 39.8%-44.6%) vs 18.1% (95% CI, 16.1%-20.0%) achieved 15% or greater weight loss within 365 days (Figure 2)

Long-term effects of sustained ERR activation on metabolism, body composition, and organ function have not been fully evaluated

Incorporating incline walking or stair climbing into your routine can help maintain muscle mass