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10.1016/j.eclinm.2024.102726
Given the complexity and increasing choice of treatment options for diabetes, shared decision-making is key
The DPP-4 enzyme breaks down active GLP-1 within 2-3 minutes of secretion, severely limiting how long the hormone can signal satiety and coordinate metabolic responses
Semaglutide may mediate glucose transport through AMPK/SIRT1 because GLP-1RA can activate SIRT1 through cAMP-dependent PKA, and GLUT4 is a downstream of SIRT1 [45]
