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Results Here we show that in vivo genome editing enables sustained Exendin-4 secretion from liver cells, leading to prolonged elevation of Exendin-4 levels in the bloodstream

Insulin Regulation of the Glucagon Gene Is Mediated by an Insulin-Responsive DNA Element

This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (10, 19)

Diabetes (2012) 61(11):296779