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Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)

Every time I look at these sequences, Im drawn back to the fascinating story of how Exenatide came to light
The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )

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