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Even though neither Balaram nor Karle worked on GLP-1 biology or drug development, their work provided the conceptual and structural scaffolding that made semaglutide possible

Wegovy is administered as a once-weekly subcutaneous injection, with doses gradually increased over 1620 weeks to the maintenance dose of 2.4 mg (or 1.7 mg if the higher dose is not tolerated)

It may lose potency unpredictably

ASA 81 mg is as effective as ASA 325 mg for reducing cardiovascular events ASA 325 mg does not cause more bleeding episodes than ASA 81 mg ASA dosing should be based on a clinician-patient risk discussion incorporating patients risk profile and their values and preferences Future trials should ensure adequate representation of women and race/ethnic minorities The results of the present trial suggest that either dose of ASA (81 mg or 325 mg) would be adequate to lower patients risk of death or atherosclerotic cardiovascular events with similar risk of bleeding