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Another contraindication is the presence of multiple endocrine neoplasia syndrome type 2 (MEN 2)

Your team may suggest temporary switches (such as injectable methotrexate) or a brief dose adjustment until side effects settle
Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes 2024. American Diabetes Association, December 11, 2023

This widespread distribution is exactly why GLP-1 receptor agonists show effects that extend far beyond weight management
