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In this sense, prior works have related menstrual cycles variations with gut microbiota, and nowadays it is widely accepted that there are certain microorganisms directly implicated in the metabolism and effects mediated by estrogens and sex hormones, conforming what is designed as the estrobolome [361]

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And, Changing patterns of contraceptive use show routine contraception utilization down by 3% in 2023, and at the same time, emergency contraception use and sterilization visits up 35% and 11%, respectively

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For example, the extension could be accompanied by differentiated pricing programs for the SUS (Unified Health System) or compulsory licensing clauses in health emergency situations

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Previously approved PAs expire Dec 31, 2025

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