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In addition, GLP-1 therapies affect body composition by reducing not only fat mass but also lean mass, a concern that is particularly relevant for at-risk groups such as older patients and those with sarcopenic obesity [[7], [8], [9]]

For context, 44% of Wegovy-treated participants experienced nausea, 30% diarrhea, and 24% constipation

Losing weight is a common goal for many, but sustainable results can feel out of reach

Despite the strength in the large cumulative sample size and compilation of data from the statistically robust design of RCTs, one of the major limitations of meta-analysis studies for retinopathy is the lack of standardization in reporting and detecting retinopathy across the included trials