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However, severe or persistent vomiting, inability to keep fluids down, or signs of dehydration warrant immediate medical attention

Some patients report that night-time dosing allows them to sleep through initial side effects, though there is no conclusive clinical evidence that timing categorically reduces nausea

FIGURE 3 Berberine increased the expression of PKA, PC1/3, PC2, and Pdx1 In the pancreas, we observed PC1/3 and PC2 under X400 microscope by immunohistochemical method (Figures 4A, B)

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