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In vitro: Exendin-4 showed a pronounced effect on intracellular cAMP generation

A study in The New England Journal of Medicine found that 59 percent of patients with NASH (non-alcoholic steatohepatitis) who took a high dose of semaglutide for 72 weeks saw improvement without worsening of fibrosis (or scarring)

Collectively, the existing preclinical and clinical data suggest that GLP-1 is involved in the pathogenesis of alcohol dependence disorders, and GLP-1R is a promising target for the development of appropriate drugs [88]

The weight management segment is projected to grow at a CAGR of 13.11% during the forecast period, driven by increasing adoption of GLP-1 therapies among obesity-management consumers and rising demand for companion supplements