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In contrast, Semaglutide maintains the GLP-1 (737) backbone, incorporates Aib8 and Arg34 modifications, and features a shorter C-18 lipid chain at Lys26, achieving weekly dosing while targeting only GLP-1 receptors 33
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Y., Zhang, Y., Yu, H., Cooper, R., Smidt, C., & Zhu, J
In contrast, neurons expressing a CaMKK2 mutant that mimics the effect of lithium by blocking GSK3 phosphorylation of the S3-node, display normal neurite outgrowth and polarity [33, 40]
