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These drugs not only provide unprecedented efficacy and acceptable safety in weight reduction and glycemic control for patients with obesity and Type 2 diabetes but also hold promise in broader indications, including neurodegenerative disorders, fatty liver disease, dyslipidemia, atherosclerosis, and cardiovascular conditions

A clinically significant interaction exists between tirzepatide and oral contraceptives, with FDA labeling advising use of non-oral or backup contraception for 4 weeks after initiation and each dose increase

Several companies already have novel drug candidates in the late stages of clinical trials that offer weekly or monthly dosing options instead of daily injections

However, it remains uncertain whether these observations reflect direct modulation of aging-related mitochondrial decline or secondary improvements resulting from restored metabolic homeostasis